منابع مشابه
Computational insights into Caenorhabditis elegans vulval development.
Studies of Caenorhabditis elegans vulval development provide a paradigm for pattern formation during animal development. The fates of the six vulval precursor cells are specified by the combined action of an inductive signal that activates the EGF receptor mitogen-activated PK signaling pathway (specifying a primary fate) and a lateral signal mediated by LIN-12/Notch (specifying a secondary fat...
متن کاملTranscriptional network underlying Caenorhabditis elegans vulval development.
The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression of cell-type-specific genes is regulated. Ras and Wnt signaling pathways play...
متن کاملNegative Regulators of Caenorhabditis elegans Vulval Development
During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-3 growth factor, the let-23 receptor tyrosine kinase, and let-60 ras. lin-15 is a negative regulator of this inductive pathway. In lin-15 muta...
متن کاملPredictive modeling of C. elegans vulval development Fisher et al. Predictive Modeling of Signaling Crosstalk during C. elegans Vulval Development
Caenorhabditis elegans vulval development provides an important paradigm for studying the process of cell fate determination and pattern formation during animal development. Although many genes controlling vulval cell fate specification have been identified, how they orchestrate to generate a robust and invariant pattern of cell fates is not yet completely understood. Here, we have developed a ...
متن کاملReversal of cell fate determination in Caenorhabditis elegans vulval development.
In Caenorhabditis elegans, the fates of the multipotent vulval precursor cells (VPCs) are specified by intercellular signals. The VPCs divide in the third larval stage (L3) of the wild type, producing progeny of determined cell types. In lin-28 mutants, vulva development is similar to wild-type vulva development except that it occurs precociously, in the second larval stage (L2). Consequently, ...
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ژورنال
عنوان ژورنال: WormBook
سال: 2005
ISSN: 1551-8507
DOI: 10.1895/wormbook.1.6.1